Ti6Al4V is the most commonly used alloy, because of its well-balanced property profile. Different heat treatments allow to tune microstructure and properties for different requirements and applications. During the use phase of powder, effects like out-washing of fine fractions, pick up of oxygen as well as enrichment of splashes change powder characteristics. In addition, there is a possibility of powder decomposition due to the powder handling process. Therefore, the powder quality permanently changes during the manufacturing process. Another point is the lot to lot variation of the powder quality inside the specified ranges. Scope of this project was to investigate the influence of relevant changes of powder characteristics on material as well as part properties.